Abstract Relapse is a major clinical problem and
remains a major challenge in the treatment of addictions. A
goal of current research is to gain a greater understanding
of the neurochemistry underlying relapse to opiate use.
Factors which trigger relapse in humans such as stress,
exposure to opiates and/or drug-associated cues, can also
trigger opiate-seeking in animals. This review will overview
preclinical studies relating to the neurochemistry of
opiate-seeking with a focus on studies published from 2005
to present.

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