ABSTRACT
Six cases heroin abusers, during withdrawal, were given iv normal saline and
dynorphin-(1-13), respectively. After saline a slight placebo effect was noticed.
When dynorphin-(1-13) given iv, withdrawal scores were lowered significantly. This
result suggests that dynorphin-(1-13) can suppress withdrawal syndrome. The side
effects due to dynorphin-(1-13) were very minimal.

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